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May 2017

L- Carnosine supplementation and its effect on diabetes

By Samuel Kolodney 1 years ago 1617 Views No comments

Research indicates many benefits of L-carnosine supplementation including increased mass of insulin producing beta-cells and a delay in diabetic cataract formation by protecting retinal capillaries from damage due to high blood sugars.

L- carnosine has also been found to inhibit the oxidation of “bad” LDL cholesterol, which in turn helps reduce the potential of oxidized LDL clogging arteries - a major cause of heart disease. Additionally, it helps prevent glycation, which in turn helps reduce the incidence of nerve damage, lower A1C levels and even help reduce wrinkled skin and other cell damage associated with aging.

Another benefit of L-carnosine supplementation is the potential to lower blood glucose levels. Data suggest that carnosine supplementation may be an effective strategy for prevention of type 2 diabetes. https://www.ncbi.nlm.nih.gov/pubmed/27040154

With so many health benefits including anti-aging effects L- carnosine should be included in everyone’s supplementation regimen.

Check out L-carnosine.

​DHEA counteracts AGE(Advanced Glycation End product) formation

By Dr. Richard K Bernstein 1 years ago 540 Views No comments

This is an article published in Diabetes Care a number of years ago, but it's still pertinent. I stumbled upon it when I go through my reminders of important facts.

Many people have asked me on these tele-seminars over the years, how do we stop glycation of proteins in the body? That assumes that you're going to have elevated blood sugars. We know that most of the complications of diabetes are caused by the attachment of glucose to important proteins throughout the body.

We've gone into detail about some of these things in the past, and if we could stop this from happening, we could prevent many of the complications of diabetes. Well, the best way to stop this from happening is to have normal blood sugars, and as those of you who are using my book, Diabetes Solution know, that's not too hard to do.

But you have to control your overeating if you eat too much carbohydrate, and you have to stop following the ADA Guidelines that recommend high carbohydrate. So number one is, normalize blood sugars. For those people who can't possibly control their overeating, DHEA, which is dehydroepiandrosterone and is a precursor to testosterone and estrogen, is something that apparently inhibits glycosolation of proteins.

For those of you who want to go to the original source, the article is entitled "Dehydroepiandrosterone Administration Counteracts Oxidative Imbalance and Advanced Glycation End Product Formation in Type 2 Diabetic Patients" This is from Diabetes Care Volume 30, 2007. You can access the PDF here.

Now, DHEA you can purchase at most health food stores. I can't testify about the quality of all different sources of DHEA. You have to use a reliable manufacturer, and you don't want to overdose yourself. So I would think that, depending upon your size, and certainly not for children, we would probably take 25 or 50 mg per day. But this is speculation based upon one article in one major journal, so that's about the information that I can give you. Shop for DHEA

How do I check the precision and accuracy of my blood glucose meter?

By Richard K Bernstein 1 years ago 1772 Views No comments

You can check the precision of your blood sugar meter and even possibly the accuracy.

Here's the method Dr. Richard Bernstein uses to enable you to check the precision (reproducible results) of your blood sugar meter and even possibly the accuracy.

As you probably know, most of the blood sugar meters on the market, according to studies that have already been published, are grossly inaccurate. I see the best accuracy, especially around normal values – so I consider normal values around 80, except with children, in the 70s, and how do you do that? Well, one could say, “Let's look at the control solutions or test solutions that the manufacturers provide with their meters.” The trouble is that, nowadays, most of the manufacturers are not providing normal controls – it has to do with some FDA guidelines that don't make sense and they're doing the minimum that they have to do to comply with FDA regulations – so they usually have control solutions that would read somewhere around 30 or 40 milligrams per deciliter, on the one end, and another solution that would read around 300 milligrams per deciliter. Now how do you now, measure for accuracy? I'm not interested in precise accuracy at a blood sugar of 30 or at a blood sugar of 300; I want it accurate where most of my patients' blood sugars are, which would be, let's say, between 80 and 100.

So how do I get this, and how do I go about testing? Well, what we do is we get hold of the manufacturer's control solutions to a meter, and we use 3 parts of the low control, which might be 30 or 40, as the middle of the range, and 1 part of the high control, and we put them in a little plastic squeeze bottle or in a glass dropper bottle that has a tight seal 'cause you don't want evaporation – evaporation will make the concentration of glucose go up – and this mixture will have a blood sugar of somewhere around 100 – it might be 108; it might be 113; it might be 97 – and you could calculate what that value would be by taking the middle value of the low control – so let's say the low control is 30 to 70: you can get the middle value by adding 30 and 70 and dividing by 2, and you get 50. And if the high control is 200 to 400, the middle value would be 300, so we would take 3 parts of the low control, so 3 times 50 would be 150, and we'd add in 1 high control, which would be 300, so that adds up to 450, and we've taken a total of 4 samples, 3 and 1, so we divide 450 by 4 and you get something like 112. So this solution should read at 112 milligrams per deciliter. So if the solution is accurate, if the manufacturer's provided you with accurate control solutions, then it's a good test of the accuracy of the meter – it should read that value that I just told you, of 112.

Now, just as important or more important, is the precision or reproducible results. What if you did 10 tests in a row, would they all read 104? And what we find, with most of these meters, is that they're scattered over a wide range. In fact, we found that one of the most popular-selling meters, a meter that many of the insurance companies require for diabetics, instead of the most accurate one, reads chronically low and may read very low or very haphazardly. So that particular meter, you might think you're going to get a reading of 104, and you get a 160 or you get 50 – that's how wide a range of readings you get with some meters – and, therefore, you do 5 or 10 tests in a row, you get a load of different numbers. On other meters, like the one that we recommend and we've mentioned it before, we get the same value over and over and over again, plus or minus one or two milligram per deciliter. So that shows consistency. And then if our reading is almost on the nose with the value of our control solution, we can be fairly confident of the accuracy, but we're assuming that the manufacturer made accurate control solutions. So the only way to be absolutely sure of the accuracy is to do a blood sugar at the clinical lab, while they're drawing blood from your arm, and see how it compares.

​What is a normal fasting blood sugar?

By Samuel Kolodney 1 years ago 819 Views No comments

There is a lot of information about “normal” blood sugar levels floating around the internet from many sources but the science paints a clear picture that isn’t always described by the various recommendations.

I find it interesting that the American Diabetes Association, along with other reputable organizations, suggests blood glucose level targets for most nonpregnant adults with diabetes that do not account for the relative risks of higher blood sugars. An example of this is the ADA recommendation of a fasting blood sugar of between 80–130 mg/dl. You can see the recommendation at this link

This number leaves out mention of a study published on another ADA website that concludes:

Fasting blood glucose values in the upper normal range appears to be an important independent predictor of cardiovascular death in nondiabetic apparently healthy middle-aged men.

More importantly, the study describes the “upper normal range” as being above 85mg/dl.

You can read an abstract of the study for yourself here.

The question that immediately comes to my mind is why do the suggested numbers in this recommendation skew dangerously high? The facts contained in the study clearly point to the need to keep fasting blood sugars below 85. In fact, Dr. Richard K. Bernstein maintains his blood sugar at 83 mg/dl and as a type 1 diabetic has kept them there for the last 50 years. He is now 82 years old and has no complications commonly associated with diabetes.

The research shows the optimal fasting blood sugar is between 80-84 mg/dl

Dr. Bernstein details how to achieve normal blood sugars in his best-selling book Diabetes Solution. Learn more at: www.diabetes-book.com

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